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Intradermal injection of platelet-rich plasma for periorbital wrinkles: A review

  • Elissa Koeswanto ,
  • Ketut Kwartantaya Winaya ,


Background: Intradermal injection of autologous platelet-rich plasma (PRP) is a non-surgical cosmetic procedure that can restore pathologies such as wrinkles in the periorbital area. Over the past decade, this new treatment has gained worldwide acceptance. We aimed to narratively review the effect of intradermal injection of PRP on the improvement of periorbital wrinkles.

Methods: This was a narrative review evaluating PRP treatment of periorbital wrinkles. Literature searching was performed using the keywords (platelet-rich plasma) AND (periorbital wrinkle) to obtain eligible articles. The literature search was performed in the PubMed database. The findings in the included articles were reviewed and described narratively.

Results: Eight studies treating 83 patients (100% female, age range 26-65) were included. PRP treatment of periorbital wrinkles resulted in objective improvement, increased subjective satisfaction scores, and a blinded evaluation of skin appearance renewal. Future studies need to address the limitations of the current literature and include long-term follow-up, randomized controlled trials with low risk of bias and absence of conflicts of interest or industry sponsors.

Conclusion: Objective and subjective assessments show that this treatment is promising for the prevention of periorbital wrinkles


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How to Cite

Koeswanto, E., & Winaya, K. K. . (2024). Intradermal injection of platelet-rich plasma for periorbital wrinkles: A review. Intisari Sains Medis, 15(1), 219–223.




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Elissa Koeswanto
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Ketut Kwartantaya Winaya
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